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Publikationen

2024

Grundei L-L, Wolf TE, Brandes F, Schütte K, Freise F, Siebert U, Touma C, Pees M (2024). Validation of fecal glucocorticoid metabolites as non-invasive markers for monitoring stress in common buzzards (Buteo buteo). Animals. 14(8):1234.

Puls F, Kosin L-M, Garbisch F, Touma C, Thöne-Reineke C, Gygax L (2024). Steps into a small world: First glimpses on everyday moment-to-moment decision making in an ecologically meaningful multi-choice system for assessing animal preferences. Ethology. 130:e13468.

Sroka MGU, Ambrée O, Dohmen C, Palme R, Kaiser S, Richter SH (2024). Personality matters – The interplay between consistent individual differences and mouse welfare in female C57BL6/J mice. Frontiers in Animal Science. 5:10.3389.

Wolf  TE, Toppel K, Jacobsen L, Andersson R, Touma C (2024). Measuring urofecal glucocorticoid metabolites in broiler chicken: a noninvasive tool for assessing stress as a marker of welfare. Poultry Science. 103(11):104162.

2023

Devoght J, Comhair J, Morelli G, Rigo J-M, D'Hooge R, Touma C, Palme R, Dewachter I, vandeVen M, Harvey R J, Schiffmann S N, Piccart E, Brône B (2023). Dopamine-mediated striatal activity and function is enhanced in GlyRα2 knockout animals. iScience 26(8): 107400.

Rappeneau V, Koti P, Wilmes L, Widner-Andrea R, Busch K, Touma C (2023). Molecular changes in hippocampal energy metabolism in mice selectively bred for extremes in stress reactivity: Relevance of mitochondrial dysfunction for affective disorders. Eur. J. Neurosci. 58(2): 2579-2602.

Wittek L, Touma C, Nitezki T, Laeger T, Krämer S, Raila J (2023). Reduction in Cold Stress in an Innovative Metabolic Cage Housing System Increases Animal Welfare in Laboratory Mice. Animals 13(18): 2866.

2022

Jaric I, Voelkl B, Clerc M, Schmid MW, Novak J, Rosso M, Rufener R, von Kortzfleisch VT, Richter SH, Buettner M, Bleich A, Amrein I, Wolfer DP, Touma C, Sunagawa S, Würbel H (2022). The rearing environment persistently modulates mouse phenotypes from the molecular to the behavioural level. PLoS Biol 20(10): e3001837.

Novak J, Jaric I, Rosso M, Rufener R, Touma C, Würbel H (2022). Handling method affects measures of anxiety, but not chronic stress in mice. sci. rep. 12:20938.

von Kortzfleisch VT, Ambrée O, Karp NA, Meyer N, Novak J, Palme R, Rosso M, Touma C, Würbel H, Kaiser S, Sachser N, Richter SH (2022). Do multiple experimenters improve the reproducibility of animal studies? PLoS Biol 20(5): e3001564.

Ziemens D, Touma C, Rappeneau V (2022). Neurobiological Mechanisms Modulating Emotionality, Cognition and Reward-Related Behaviour in High-Fat Diet-Fed Rodents. Int J Mol Sci 23: 7952.

2021

Herrmann L, Ebert T, Rosen H, Novak B, Philipsen A, Touma C, Schreckenbach M, Gassen NC, Rein T, Schmidt U (2021). Analysis of the cerebellar molecular stress response led to first evidence of a role for FKBP51 in brain FKBP52 expression in mice and humans. Neurobiol Stress 15: 100401.

Hofmann J, Huber C, Novak B, Schreckenbach M, Schubert CF, Touma C, Rutten BP, Schmidt U (2021). Oxytocin receptor is a potential biomarker of the hyporesponsive HPA axis subtype of PTSD and might be modulated by HPA axis reactivity traits in humans and mice. Psychoneuroendocrinology 129:105242.

Huzard D, Rappeneau V, Meijer OC, Touma C, Arango-Lievano M, Garabedian MJ, Jeanneteau F (2021). Experience and activity-dependent control of glucocorticoid receptors during the stress response in large-scale brain networks. Stress 24(2): 130-153.

Kroll T, Kornadt-Beck N, Oskamp A, Elmenhorst D, Touma C, Palme R, Bauer A (2021). Additional assessment of fecal corticosterone metabolites improves visual rating in the evaluation of stress responses of laboratory rats. Animals 11: 710.

Leite Dantas R, Freff J, Ambree O, Beins EC, Forstner AJ, Dannlowski U, Baune BT, Scheu S, Alferink J (2021). Dendritic Cells: Neglected Modulators of Peripheral Immune Responses and Neuroinflammation in Mood Disorders? Cells 10(4):941.

Tobinski AM, Rappeneau V (2021). Role of the Neuropeptide S System in Emotionality, Stress Responsiveness and Addiction-Like Behaviours in Rodents: Relevance to Stress-Related Disorders. Pharmaceuticals 14(8): 780.

2020

Harrison DJ, Creeth HDJ, Tyson HR, Boque-Sastre R, Isles AR, Palme R, Touma C, John RM (2020). Unified Behavioral Scoring for Preclinical Models. Front Neurosci 14: 313.

Meyer N, Kröger M, Thümmler J, Tietze L, Palme R, Touma C (2020). Impact of three commonly used blood sampling techniques on the welfare of laboratory mice: Taking the animal's perspective. PLoS One 15: e0238895.

Rappeneau V, Wilmes L, Touma C (2020). Molecular correlates of mitochondrial dysfunctions in major depression: Evidence from clinical and rodent studies. Mol Cell Neurosci 109: 103555.

2019

Ambree O, Ruland C, Zwanzger P, Klotz L, Baune BT, Arolt V, Scheu S and Alferink J (2019). Social Defeat Modulates T Helper Cell Percentages in Stress Susceptible and Resilient Mice. Int J Mol Sci 20: 3512.

Forkosh O, Karamihalev S, Roeh S, Alon U, Anpilov S, Touma C, Nussbaumer M, Flachskamm C, Kaplick PM, Shemesh Y, Chen A (2019). Identity domains capture individual differences from across the behavioral repertoire. Nat Neurosci 22: 2023-2028.

Golub Y, Schildbach EM, Touma C, Kratz O, Moll GH, von Horsten S and Canneva F (2019). Role of hypothalamus-pituitary-adrenal axis modulation in the stress-resilient phenotype of DPP4-deficient rats. Behav Brain Res 356: 243-249.

Hohoff C, Zhang M, Ambree O, Kravchenko M, Buschert J, Kerkenberg N, Gorinski N, Abdel Galil D, Schettler C, Vom Werth KL, Wewer MF, Schneider I, Grotegerd D, Wachsmuth L, Faber C, Skryabin BV, Brosius J, Ponimaskin E and Zhang W (2019). Deficiency of the palmitoyl acyltransferase ZDHHC7 impacts brain and behavior of mice in a sex-specific manner. Brain Struct Funct 224: 2213-2230.

Rein T, Ambree O, Fries GR, Rappeneau V, Schmidt U and Touma C (2019). The hypothalamic-pituitary-adrenal axis in depression: Molecular regulation, pathophysiological role, and translational implications. In J Quevedo, AF Carvalho and CA Zarate (Eds.), Neurobiology of depression: Road to novel therapeutics. London, UK, Academic Press: 89-96.

2018

Ahmetspahic D, Schwarte K, Ambree O, Burger C, Falcone V, Seiler K, Kooybaran MR, Grosse L, Roos F, Scheffer J, Jorgens S, Koelkebeck K, Dannlowski U, Arolt V, Scheu S and Alferink J (2018). Altered B Cell Homeostasis in Patients with Major Depressive Disorder and Normalization of CD5 Surface Expression on Regulatory B Cells in Treatment Responders. J Neuroimmune Pharmacol 13: 90-99.

Ambree O, Ruland C, Scheu S, Arolt V and Alferink J (2018). Alterations of the Innate Immune System in Susceptibility and Resilience After Social Defeat Stress. Front Behav Neurosci 12: 141.

Razzoli M, Nyuyki-Dufe K, Gurney A, Erickson C, McCallum J, Spielman N, Marzullo M, Patricelli J, Kurata M, Pope EA, Touma C, Palme R, Largaespada DA, Allison DB and Bartolomucci A (2018). Social stress shortens lifespan in mice. Aging Cell e12778.

Ruland C, Berlandi J, Eikmeier K, Weinert T, Lin FJ, Ambree O, Seggewiss J, Paulus W and Jeibmann A (2018). Decreased Cerebral Irp-1B Limits Impact of Social Isolation in Wildtype and Alzheimer's Disease Modelled in Drosophila melanogaster. Genes Brain Behav 17: e12451.

Schneider I, Kugel H, Redlich R, Grotegerd D, Burger C, Burkner PC, Opel N, Dohm K, Zaremba D, Meinert S, Schroder N, Strassburg AM, Schwarte K, Schettler C, Ambree O, Rust S, Domschke K, Arolt V, Heindel W, Baune BT, Zhang W, Dannlowski U and Hohoff C (2018). Association of Serotonin Transporter Gene AluJb Methylation with Major Depression, Amygdala Responsiveness, 5-HTTLPR/rs25531 Polymorphism, and Stress. Neuropsychopharmacology 43: 1308-1316.

Shimamoto A, Rappeneau V, Munjal H, Farris T, Davis C, Wilson A, Edwards M, Moore C, Reynolds C and Meshul CK (2018). Glutamate-Glutamine Transfer and Chronic Stress-Induced Sex Differences in Cocaine Responses. Neuroscience 391: 104-119.

Weidt A, Gygax L, Palme R, Touma C and Konig B (2018). Impact of male presence on female sociality and stress endocrinology in wild house mice (Mus musculus domesticus). Physiol Behav 189: 1-9.

2017

Benedetti F, Ambree O, Locatelli C, Lorenzi C, Poletti S, Colombo C and Arolt V (2017). The effect of childhood trauma on serum BDNF in bipolar depression is modulated by the serotonin promoter genotype. Neurosci Lett 656: 177-181.

Berlandi J, Lin FJ, Ambree O, Rieger D, Paulus W and Jeibmann A (2017). Swing Boat: Inducing and Recording Locomotor Activity in a Drosophila melanogaster Model of Alzheimer's Disease. Front Behav Neurosci 11: 159.

Gurfein, BT, Hasdemir B, Milush JM, Touma C, Palme R, Nixon DF, Hecht FM, Darcel N, Bhargava A (2017). Enriched environment and stress exposure influence splenic B lymphocyte composition. PLoS One 12(7): e0180771.

McIlwrick S, Pohl T, Chen A and Touma C (2017). Late-onset cognitive impairments after early-life stress are shaped by inherited differences in stress reactivity. Front Cell Neurosci 11:9. doi: 10.3389/fncel.2017.00009.

Jeibmann A, Schulz J, Eikmeier K, Johann PD, Thiel K, Tegeder I, Ambree O, Fruhwald MC, Pfister SM, Kool M, Paulus W and Hasselblatt M (2017). SMAD dependent signaling plays a detrimental role in a fly model of SMARCB1-deficiency and the biology of atypical teratoid/rhabdoid tumors. J Neurooncol 131: 477-484.

Poletti S, Aggio V, Hoogenboezem TA, Ambree O, de Wit H, Wijkhuijs AJ, Locatelli C, Colombo C, Arolt V, Drexhage HA and Benedetti F (2017). Brain-derived Neurotrophic Factor (BDNF) and gray matter volume in bipolar disorder. Eur Psychiatry 40: 33-37.

Rappeneau V, Bérod A (2017). Reconsidering depression as a risk factor for substance use disorder: Insights from rodent models. Neurosci Biobehav Rev 77: 303-316.

Sakalem ME, Seidenbecher T, Zhang M, Saffari R, Kravchenko M, Wordemann S, Diederich K, Schwamborn JC, Zhang W and Ambree O (2017). Environmental enrichment and physical exercise revert behavioral and electrophysiological impairments caused by reduced adult neurogenesis. Hippocampus 27: 36-51.

Shimamoto A and Rappeneau V (2017). Sex-dependent mental illnesses and mitochondria. Schizophr Res 187: 38-46.

2016

Ambree O, Bergink V, Grosse L, Alferink J, Drexhage HA, Rothermundt M, Arolt V and Birkenhager TK (2016). S100B Serum Levels Predict Treatment Response in Patients with Melancholic Depression. Int J Neuropsychopharmacol 19: pyv103.

Ambree O, Klassen I, Forster I, Arolt V, Scheu S and Alferink J (2016). Reduced locomotor activity and exploratory behavior in CC chemokine receptor 4 deficient mice. Behav Brain Res 314: 87-95.

Benedetti F, Poletti S, Hoogenboezem TA, Locatelli C, Ambree O, de Wit H, Wijkhuijs AJ, Mazza E, Bulgarelli C, Vai B, Colombo C, Smeraldi E, Arolt V and Drexhage HA (2016). Stem Cell Factor (SCF) is a putative biomarker of antidepressant response. J Neuroimmune Pharmacol 11: 248-258.

Benedetti F, Poletti S, Hoogenboezem TA, Mazza E, Ambree O, de Wit H, Wijkhuijs AJ, Locatelli C, Bollettini I, Colombo C, Arolt V and Drexhage HA (2016). Inflammatory cytokines influence measures of white matter integrity in Bipolar Disorder. J Affect Disord 202: 1-9.

Bose J, Kloesener MH and Schulte RD (2016). Multiple-genotype infections and their complex effect on virulence. Zoology (Jena) 119: 339-349.

Buschert J, Sakalem ME, Saffari R, Hohoff C, Rothermundt M, Arolt V, Zhang W and Ambree O (2016). Prenatal immune activation in mice blocks the effects of environmental enrichment on exploratory behavior and microglia density. Prog Neuropsychopharmacol Biol Psychiatry 67: 10-20.

Grosse L, Hoogenboezem T, Ambree O, Bellingrath S, Jorgens S, de Wit HJ, Wijkhuijs AM, Arolt V and Drexhage HA (2016). Deficiencies of the T and natural killer cell system in major depressive disorder: T regulatory cell defects are associated with inflammatory monocyte activation. Brain Behav Immun 54: 38-44.

Grosse L, Ambree O, Jorgens S, Jawahar MC, Singhal G, Stacey D, Arolt V and Baune BT (2016). Cytokine levels in major depression are related to childhood trauma but not to recent stressors. Psychoneuroendocrinology 73: 24-31.

McIlwrick S, Rechenberg A, Matthes M, Burgstaller J, Schwarzbauer T, Chen A and Touma C (2016). Genetic predisposition for high stress reactivity amplifies effects of early-life adversity. Psychoneuroendocrinology 70: 85-97.

Rappeneau V, Blaker A, Petro JR, Yamamoto BK and Shimamoto A (2016). Disruption of the Glutamate-Glutamine Cycle Involving Astrocytes in an Animal Model of Depression for Males and Females. Front Behav Neurosci 10: 231.

Saffari R, Teng Z, Zhang M, Kravchenko M, Hohoff C, Ambree O and Zhang W (2016). NPY+-, but not PV+- GABAergic neurons mediated long-range inhibition from infra- to prelimbic cortex. Transl Psychiatry 6: e736.

Surget A, Van Nieuwenhuijzen PS, Heinzmann JM, Knapman A, McIlwrick S, Westphal WP, Touma C and Belzung C (2016). Antidepressant treatment differentially affects the phenotype of high and low stress reactive mice. Neuropharmacology 110: 37-47.

2015

Bluhm B, Laffer B, Hirnet D, Rothermundt M, Ambree O and Lohr C (2015). Normal cerebellar development in S100B-deficient mice. Cerebellum 14: 119-127.

Gaali S, Kirschner A, Cuboni S, Hartmann J, Kozany C, Balsevich G, Namendorf C, Fernandez-Vizarra P, Sippel C, Zannas AS, Draenert R, Binder EB, Almeida OF, Ruhter G, Uhr M, Schmidt MV, Touma C, Bracher A and Hausch F (2015). Selective inhibitors of the FK506-binding protein 51 by induced fit. Nat Chem Biol 11: 33-37.

Grosse L, Carvalho LA, Wijkhuijs AJ, Bellingrath S, Ruland T, Ambree O, Alferink J, Ehring T, Drexhage HA and Arolt V (2015). Clinical characteristics of inflammation-associated depression: Monocyte gene expression is age-related in major depressive disorder. Brain Behav Immun 44: 48-56.

Hennings JM, Uhr M, Klengel T, Weber P, Putz B, Touma C, Czamara D, Ising M, Holsboer F and Lucae S (2015). RNA expression profiling in depressed patients suggests retinoid-related orphan receptor alpha as a biomarker for antidepressant response. Transl Psychiatry 5: e538.

Masri L, Branca A, Sheppard AE, Papkou A, Laehnemann D, Guenther PS, Prahl S, Saebelfeld M, Hollensteiner J, Liesegang H, Brzuszkiewicz E, Daniel R, Michiels NK, Schulte RD, Kurtz J, Rosenstiel P, Telschow A, Bornberg-Bauer E and Schulenburg H (2015). Host-Pathogen Coevolution: The Selective Advantage of Bacillus thuringiensis Virulence and Its Cry Toxin Genes. PLoS Biol 13: e1002169.

Mesman E, Hillegers MH, Ambree O, Arolt V, Nolen WA and Drexhage HA (2015). Monocyte activation, brain-derived neurotrophic factor (BDNF), and S100B in bipolar offspring: a follow-up study from adolescence into adulthood. Bipolar Disord 17: 39-49.

Rappeneau V, Morel AL, El Yacoubi M, Vaugeois JM, Denoroy L and Berod A (2015). Enhanced Cocaine-Associated Contextual Learning in Female H/Rouen Mice Selectively Bred for Depressive-Like Behaviors: Molecular and Neuronal Correlates. Int J Neuropsychopharmacol 18: pyv022.

Schmidt U, Buell DR, Ionescu IA, Gassen NC, Holsboer F, Cox MB, Novak B, Huber C, Hartmann J, Schmidt MV, Touma C, Rein T and Herrmann L (2015). A role for synapsin in FKBP51 modulation of stress responsiveness: Convergent evidence from animal and human studies. Psychoneuroendocrinology 52: 43-58.

2014

Ambree O, Buschert J, Zhang W, Arolt V, Dere E and Zlomuzica A (2014). Impaired spatial learning and reduced adult hippocampal neurogenesis in histamine H1-receptor knockout mice. Eur Neuropsychopharmacol 24: 1394-1404.

Bose J and Schulte RD (2014). Testing GxG interactions between coinfecting microbial parasite genotypes within hosts. Front Genet 5: 124.

Dannlowski U, Kugel H, Redlich R, Halik A, Schneider I, Opel N, Grotegerd D, Schwarte K, Schettler C, Ambree O, Rust S, Domschke K, Arolt V, Heindel W, Baune BT, Suslow T, Zhang W and Hohoff C (2014). Serotonin transporter gene methylation is associated with hippocampal gray matter volume. Hum Brain Mapp 35: 5356-5367.

Gurfein BT, Davidenko O, Premenko-Lanier M, Milush JM, Acree M, Dallman MF, Touma C, Palme R, York VA, Fromentin G, Darcel N, Nixon DF and Hecht FM (2014). Environmental enrichment alters splenic immune cell composition and enhances secondary influenza vaccine responses in mice. Mol Med 20: 179-190.

Heinzmann JM, Kloiber S, Ebling-Mattos G, Bielohuby M, Schmidt MV, Palme R, Holsboer F, Uhr M, Ising M and Touma C (2014). Mice selected for extremes in stress reactivity reveal key endophenotypes of major depression: a translational approach. Psychoneuroendocrinology 49: 229-243.

Krohn J, Speed D, Palme R, Touma C, Mott R and Flint J (2014). Genetic interactions with sex make a relatively small contribution to the heritability of complex traits in mice. PLoS One 9: e96450.

Sotnikov S, Wittmann A, Bunck M, Bauer S, Deussing J, Schmidt M, Touma C, Landgraf R and Czibere L (2014). Blunted HPA axis reactivity reveals glucocorticoid system dysbalance in a mouse model of high anxiety-related behavior. Psychoneuroendocrinology 48: 41-51.

2013

Arolt V and Ambree O (2013). The question of pro-inflammatory immune activity in schizophrenia and the potential importance of anti-inflammatory drugs. Mod Trends Pharmacopsychiatri 28: 100-116.

Buschert J, Hohoff C, Touma C, Palme R, Rothermundt M, Arolt V, Zhang W and Ambree O (2013). S100B overexpression increases behavioral and neural plasticity in response to the social environment during adolescence. J Psychiatr Res 47: 1791-1799.

El Yacoubi M, Rappeneau V, Champion E, Malleret G and Vaugeois JM (2013). The H/Rouen mouse model displays depression-like and anxiety-like behaviors. Behav Brain Res 256: 43-50.

Hohoff C, Gorji A, Kaiser S, Willscher E, Korsching E, Ambree O, Arolt V, Lesch KP, Sachser N, Deckert J and Lewejohann L (2013). Effect of acute stressor and serotonin transporter genotype on amygdala first wave transcriptome in mice. PLoS One 8: e58880.

Masri L, Schulte RD, Timmermeyer N, Thanisch S, Crummenerl LL, Jansen G, Michiels NK and Schulenburg H (2013). Sex differences in host defence interfere with parasite-mediated selection for outcrossing during host-parasite coevolution. Ecol Lett 16: 461-468.

Mattos GE, Heinzmann JM, Norkowski S, Helbling JC, Minni AM, Moisan MP and Touma C (2013). Corticosteroid-binding globulin contributes to the neuroendocrine phenotype of mice selected for extremes in stress reactivity. J Endocrinol 219: 217-229.

Palme R, Touma C, Arias N, Dominchin MF and Lepschy M (2013). Steroid extraction: Get the best out of faecal samples. Wiener Tierarztliche Monatsschrift 100: 238-246.

Schulte RD, Makus C and Schulenburg H (2013). Host-parasite coevolution favours parasite genetic diversity and horizontal gene transfer. J Evol Biol 26: 1836-1840.

Voigt CC, Klockner P, Touma C, Neuschl C, Brockmann G, Goritz F, Palme R and Thomsen R (2013). Hormonal stress response of laboratory mice to conventional and minimally invasive bleeding techniques. Animal Welfare 22: 449-455.

2012

Breu J, Touma C, Holter SM, Knapman A, Wurst W and Deussing JM (2012). Urocortin 2 modulates aspects of social behaviour in mice. Behav Brain Res 233: 331-336.

Coudereau JP, Sreng L, Palme R, Touma C and Pratte M (2012). Do social statuses affect the startle reflex in male mice? Behav Brain Res 234: 117-120.

Dedic N, Touma C, Romanowski CP, Schieven M, Kuhne C, Ableitner M, Lu A, Holsboer F, Wurst W, Kimura M and Deussing JM (2012). Assessing behavioural effects of chronic HPA axis activation using conditional CRH-overexpressing mice. Cell Mol Neurobiol 32: 815-828.

Domschke K, Tidow N, Kuithan H, Schwarte K, Klauke B, Ambree O, Reif A, Schmidt H, Arolt V, Kersting A, Zwanzger P and Deckert J (2012). Monoamine oxidase A gene DNA hypomethylation - a risk factor for panic disorder? Int J Neuropsychopharmacol 15: 1217-1228.

El Hage C, Rappeneau V, Etievant A, Morel AL, Scarna H, Zimmer L and Berod A (2012). Enhanced anxiety observed in cocaine withdrawn rats is associated with altered reactivity of the dorsomedial prefrontal cortex. PLoS One 7: e43535.

Gonik M, Frank E, Kessler MS, Czamara D, Bunck M, Yen YC, Putz B, Holsboer F, Bettecken T, Landgraf R, Muller-Myhsok B, Touma C and Czibere L (2012). The endocrine stress response is linked to one specific locus on chromosome 3 in a mouse model based on extremes in trait anxiety. BMC Genomics 13: 579.

Gurfein BT, Stamm AW, Bacchetti P, Dallman MF, Nadkarni NA, Milush JM, Touma C, Palme R, Di Borgo CP, Fromentin G, Lown-Hecht R, Konsman JP, Acree M, Premenko-Lanier M, Darcel N, Hecht FM and Nixon DF (2012). The calm mouse: an animal model of stress reduction. Mol Med 18: 606-617.

Hartmann J, Wagner KV, Liebl C, Scharf SH, Wang XD, Wolf M, Hausch F, Rein T, Schmidt U, Touma C, Cheung-Flynn J, Cox MB, Smith DF, Holsboer F, Muller MB and Schmidt MV (2012). The involvement of FK506-binding protein 51 (FKBP5) in the behavioral and neuroendocrine effects of chronic social defeat stress. Neuropharmacology 62: 332-339.

Knapman A, Kaltwasser SF, Martins-de-Souza D, Holsboer F, Landgraf R, Turck CW, Czisch M and Touma C (2012). Increased stress reactivity is associated with reduced hippocampal activity and neuronal integrity along with changes in energy metabolism. Eur J Neurosci 35: 412-422.

Kolbe T, Palme R, Touma C and Rulicke T (2012). Repeated use of surrogate mothers for embryo transfer in the mouse. Biol Reprod 86: 1-6.

Pillai AG, de Jong D, Kanatsou S, Krugers H, Knapman A, Heinzmann JM, Holsboer F, Landgraf R, Joels M and Touma C (2012). Dendritic morphology of hippocampal and amygdalar neurons in adolescent mice is resilient to genetic differences in stress reactivity. PLoS One 7: e38971.

Schulte RD, Hasert B, Makus C, Michiels NK and Schulenburg H (2012). Increased responsiveness in feeding behaviour of Caenorhabditis elegans after experimental coevolution with its microparasite Bacillus thuringiensis. Biol Lett 8: 234-236.

2011

Dere E, Ambrée O, Zlomuzika A (2011). Histidine decarboxylase. In: J.P.F. D’Mello (ed.) Amino acids in human nutrition and health. Cabi Publishing, Wallingford, pp. 89-102.

Edgar NM, Touma C, Palme R and Sibille E (2011). Resilient emotionality and molecular compensation in mice lacking the oligodendrocyte-specific gene Cnp1. Transl Psychiatry 1: e42.

Engel AKJ, Gross AN, Richter SH, Rommen J, Touma C and Wurbel H (2011). Variation in stress reactivity affects cage-induced stereotypies in female CD-1 (ICR) mice. Applied Animal Behaviour Science 133: 101-108.

Fenzl T, Touma C, Romanowski CP, Ruschel J, Holsboer F, Landgraf R, Kimura M and Yassouridis A (2011). Sleep disturbances in highly stress reactive mice: modeling endophenotypes of major depression. BMC Neurosci 12: 29.

Refojo D, Schweizer M, Kuehne C, Ehrenberg S, Thoeringer C, Vogl AM, Dedic N, Schumacher M, von Wolff G, Avrabos C, Touma C, Engblom D, Schutz G, Nave KA, Eder M, Wotjak CT, Sillaber I, Holsboer F, Wurst W and Deussing JM (2011). Glutamatergic and dopaminergic neurons mediate anxiogenic and anxiolytic effects of CRHR1. Science 333: 1903-1907.

Richter SH, Garner JP, Zipser B, Lewejohann L, Sachser N, Touma C, Schindler B, Chourbaji S, Brandwein C, Gass P, van Stipdonk N, van der Harst J, Spruijt B, Voikar V, Wolfer DP and Wurbel H (2011). Effect of population heterogenization on the reproducibility of mouse behavior: a multi-laboratory study. PLoS One 6: e16461.

Schulte RD, Makus C, Hasert B, Michiels NK and Schulenburg H (2011). Host-parasite local adaptation after experimental coevolution of Caenorhabditis elegans and its microparasite Bacillus thuringiensis. Proc Biol Sci 278: 2832-2839.

Schulte RD and Schulenburg H (2011). Evolutionsökologie: Koevolution von Caenorhabditis elegans und Mikroparasiten im Labor. BioSpektrum 5: 500.

Surget A, Tanti A, Leonardo ED, Laugeray A, Rainer Q, Touma C, Palme R, Griebel G, Ibarguen-Vargas Y, Hen R and Belzung C (2011). Antidepressants recruit new neurons to improve stress response regulation. Mol Psychiatry 16: 1177-1188.

Touma C, Gassen NC, Herrmann L, Cheung-Flynn J, Bull DR, Ionescu IA, Heinzmann JM, Knapman A, Siebertz A, Depping AM, Hartmann J, Hausch F, Schmidt MV, Holsboer F, Ising M, Cox MB, Schmidt U and Rein T (2011). FK506 binding protein 5 shapes stress responsiveness: modulation of neuroendocrine reactivity and coping behavior. Biol Psychiatry 70: 928-936.

Touma C (2011). Stress and affective disorders: animal models elucidating the molecular basis of neuroendocrine-behavior interactions. Pharmacopsychiatry 44 Suppl 1: S15-26.

Varadarajulu J, Lebar M, Krishnamoorthy G, Habelt S, Lu J, Bernard Weinstein I, Li H, Holsboer F, Turck CW and Touma C (2011). Increased anxiety-related behaviour in Hint1 knockout mice. Behav Brain Res 220: 305-311.

2010

Adamson TW, Kendall LV, Goss S, Grayson K, Touma C, Palme R, Chen JQ and Borowsky AD (2010). Assessment of carprofen and buprenorphine on recovery of mice after surgical removal of the mammary fat pad. J Am Assoc Lab Anim Sci 49: 610-616.

Fuss J, Ben Abdallah NM, Vogt MA, Touma C, Pacifici PG, Palme R, Witzemann V, Hellweg R and Gass P (2010). Voluntary exercise induces anxiety-like behavior in adult C57BL/6J mice correlating with hippocampal neurogenesis. Hippocampus 20: 364-376.

Heinzmann JM, Thoeringer CK, Knapman A, Palme R, Holsboer F, Uhr M, Landgraf R and Touma C (2010). Intrahippocampal corticosterone response in mice selectively bred for extremes in stress reactivity: a microdialysis study. J Neuroendocrinol 22: 1187-1197.

Herring A, Blome M, Ambree O, Sachser N, Paulus W and Keyvani K (2010). Reduction of cerebral oxidative stress following environmental enrichment in mice with Alzheimer-like pathology. Brain Pathol 20: 166-175.

Jansen F, Heiming RS, Lewejohann L, Touma C, Palme R, Schmitt A, Lesch KP and Sachser N (2010). Modulation of behavioural profile and stress response by 5-HTT genotype and social experience in adulthood. Behav Brain Res 207: 21-29.

Knapman A, Heinzmann JM, Hellweg R, Holsboer F, Landgraf R and Touma C (2010). Increased stress reactivity is associated with cognitive deficits and decreased hippocampal brain-derived neurotrophic factor in a mouse model of affective disorders. J Psychiatr Res 44: 566-575.

Knapman A, Heinzmann JM, Holsboer F, Landgraf R and Touma C (2010). Modeling psychotic and cognitive symptoms of affective disorders: Disrupted latent inhibition and reversal learning deficits in highly stress reactive mice. Neurobiol Learn Mem 94: 145-152.

Lepschy M, Touma C and Palme R (2010). Faecal glucocorticoid metabolites: how to express yourself - comparison of absolute amounts versus concentrations in samples from a study in laboratory rats. Lab Anim 44: 192-198.

Schulte RD, Makus C, Hasert B, Michiels NK and Schulenburg H (2010). Multiple reciprocal adaptations and rapid genetic change upon experimental coevolution of an animal host and its microbial parasite. Proc Natl Acad Sci U S A 107: 7359-7364.

2009

Ambree O, Richter H, Sachser N, Lewejohann L, Dere E, de Souza Silva MA, Herring A, Keyvani K, Paulus W and Schabitz WR (2009). Levodopa ameliorates learning and memory deficits in a murine model of Alzheimer's disease. Neurobiol Aging 30: 1192-1204.

Blottner D, Serradj N, Salanova M, Touma C, Palme R, Silva M, Aerts JM, Berckmans D, Vico L, Liu Y, Giuliani A, Rustichelli F, Cancedda R and Jamon M (2009). Morphological, physiological and behavioural evaluation of a 'Mice in Space' housing system. J Comp Physiol B 179: 519-533.

Hambsch B, Czibere L, Landgraf R, Touma C (2009). Genetic transmission of behavior and its neuroendocrine correlates. In: Pfaff D, Arnold AP, Etgen AM, Fahrbach SE, Rubin RT (Eds.). Hormones, Brain and Behavior 2nd ed., Elsevier Science, San Diego CA, USA, Volume 4, Chapter84, pp. 2633-2671.

Herring A, Ambree O, Tomm M, Habermann H, Sachser N, Paulus W and Keyvani K (2009). Environmental enrichment enhances cellular plasticity in transgenic mice with Alzheimer-like pathology. Exp Neurol 216: 184-192.

Lewejohann L, Reefmann N, Widmann P, Ambree O, Herring A, Keyvani K, Paulus W and Sachser N (2009). Transgenic Alzheimer mice in a semi-naturalistic environment: more plaques, yet not compromised in daily life. Behav Brain Res 201: 99-102.

Nicholson A, Malcolm RD, Russ PL, Cough K, Touma C, Palme R and Wiles MV (2009). The response of C57BL/6J and BALB/cJ mice to increased housing density. J Am Assoc Lab Anim Sci 48: 740-753.

Touma C, Fenzl T, Ruschel J, Palme R, Holsboer F, Kimura M and Landgraf R (2009). Rhythmicity in mice selected for extremes in stress reactivity: behavioural, endocrine and sleep changes resembling endophenotypes of major depression. PLoS One 4: e4325.

2008

Gortz N, Lewejohann L, Tomm M, Ambree O, Keyvani K, Paulus W and Sachser N (2008). Effects of environmental enrichment on exploration, anxiety, and memory in female TgCRND8 Alzheimer mice. Behav Brain Res 191: 43-48.

Herring A, Yasin H, Ambree O, Sachser N, Paulus W and Keyvani K (2008). Environmental enrichment counteracts Alzheimer's neurovascular dysfunction in TgCRND8 mice. Brain Pathol 18: 32-39.

Ibarguen-Vargas Y, Surget A, Touma C, Palme R and Belzung C (2008). Multifaceted strain-specific effects in a mouse model of depression and of antidepressant reversal. Psychoneuroendocrinology 33: 1357-1368.

Kaiser S, Touma C, Galert T, Würbel H (2008). Animal suffering – fact or fiction? In: Müller K, Sachser N (Eds.). Theology Meets Biology – Anthropological Perspectives on Animals and Human Beings. Pustet Verlag, Regensburg, pp. 123-136.

Lepschy M, Rettenbacher S, Touma C and Palme RG (2008). Excretion of catecholamines in rats, mice and chicken. J Comp Physiol B 178: 629-636.

Richter H, Ambree O, Lewejohann L, Herring A, Keyvani K, Paulus W, Palme R, Touma C, Schabitz WR and Sachser N (2008). Wheel-running in a transgenic mouse model of Alzheimer's disease: protection or symptom? Behav Brain Res 190: 74-84.

Touma C, Bunck M, Glasl L, Nussbaumer M, Palme R, Stein H, Wolferstatter M, Zeh R, Zimbelmann M, Holsboer F and Landgraf R (2008). Mice selected for high versus low stress reactivity: a new animal model for affective disorders. Psychoneuroendocrinology 33: 839-862.

2007

Lepschy M, Touma C, Hruby R and Palme R (2007). Non-invasive measurement of adrenocortical activity in male and female rats. Lab Anim 41: 372-387.

Sicard M, Hering S, Schulte R, Gaudriault S and Schulenburg H (2007). The effect of Photorhabdus luminescens (Enterobacteriaceae) on the survival, development, reproduction and behaviour of Caenorhabditis elegans (Nematoda : Rhabditidae). Environmental Microbiology 9: 12-25.

2006

Ambree O, Touma C, Gortz N, Keyvani K, Paulus W, Palme R and Sachser N (2006). Activity changes and marked stereotypic behavior precede Abeta pathology in TgCRND8 Alzheimer mice. Neurobiol Aging 27: 955-964.

Ambree O, Leimer U, Herring A, Gortz N, Sachser N, Heneka MT, Paulus W and Keyvani K (2006). Reduction of amyloid angiopathy and Abeta plaque burden after enriched housing in TgCRND8 mice: involvement of multiple pathways. Am J Pathol 169: 544-552.

Dallmann R, Touma C, Palme R, Albrecht U and Steinlechner S (2006). Impaired daily glucocorticoid rhythm in Per1 ( Brd ) mice. J Comp Physiol A Neuroethol Sens Neural Behav Physiol 192: 769-775.

D'Souza TG, Schulte RD, Schulenburg H and Michiels NK (2006). Paternal inheritance in parthenogenetic forms of the planarian Schmidtea polychroa. Heredity (Edinb) 97: 97-101.

Voigtlander T, Unterberger U, Touma C, Palme R, Polster B, Strohschneider M, Dorner S and Budka H (2006). Prominent corticosteroid disturbance in experimental prion disease. Eur J Neurosci 23: 2723-2730.

2005

Palme R, Rettenbacher S, Touma C, El-Bahr SM and Mostl E (2005). Stress hormones in mammals and birds: comparative aspects regarding metabolism, excretion, and noninvasive measurement in fecal samples. Ann N Y Acad Sci 1040: 162-171.

Touma C and Palme R (2005). Measuring fecal glucocorticoid metabolites in mammals and birds: the importance of validation. Ann N Y Acad Sci 1046: 54-74.

2004

Jömann N, Junker C, Touma C (Eds.) (2004). Religion - wieso, weshalb, warum? Zur Funktion von Religion aus soziologischer, biologischer, philosophischer und theologischer Sicht. Reihe: Edition KSHG, Bd. 3, 160 Seiten, LIT Verlag Münster-Hamburg-Berlin-Wien-London.

Touma C, Ambree O, Gortz N, Keyvani K, Lewejohann L, Palme R, Paulus W, Schwarze-Eicker K and Sachser N (2004). Age- and sex-dependent development of adrenocortical hyperactivity in a transgenic mouse model of Alzheimer's disease. Neurobiol Aging 25: 893-904.

Touma C, Palme R and Sachser N (2004). Analyzing corticosterone metabolites in fecal samples of mice: a noninvasive technique to monitor stress hormones. Horm Behav 45: 10-22.

2003

 Touma C, Sachser N, Mostl E and Palme R (2003). Effects of sex and time of day on metabolism and excretion of corticosterone in urine and feces of mice. Gen Comp Endocrinol 130: 267-278.

2001

Touma C, Kurt F (2001). Ethologische Untersuchungen zur Musth bei Elefantenbullen in Menschenhand. In: Kurt F (Ed.). Elefant in Menschenhand – Forschungsberichte aus Sri Lanka. Filander Verlag, Fürth, pp. 185-196.

Touma C, Palme R and Sachser N (2001). Different types of oestrous cycle in two closely related South American rodents (Cavia aperea and Galea musteloides) with different social and mating systems. Reproduction 121: 791-801.